Tag Archive for: Obesity

Arteriolar Function in Visceral Adipose Tissue Is Impaired in Human Obesity.

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CONCLUSIONS: Our findings provide clinical evidence that the visceral microenvironment may be intrinsically toxic to arterial health providing a potential mechanism by which visceral adiposity burden is linked to atherosclerotic vascular disease. Our findings also support the evolving concept that both adipose tissue quality and quantity may play significant roles in shaping cardiovascular phenotypes in human obesity.
PMID: 22095978 [PubMed – as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

Determinants of Increased Cardiovascular Disease in Obesity and Metabolic Syndrome.

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Authors: Vazzana N, Santilli F, Sestili S, Cuccurullo C, Davì G
Abstract
Obesity is associated with an increased mortality and morbidity for cardiovascular disease (CVD) and adipose tissue is recognised as an important player in obesity-mediated CVD. The diagnosis of the metabolic syndrome (MS) appears to identify substantial additional cardiovascular risk above and beyond the individual risk factors, even though the pathophysiology underlying this evidence is still unravelled. The inflammatory response related to fat accumulation may influence cardiovascular risk through its involvement not only in body weight homeostasis, but also in coagulation, fibrinolysis, endothelial dysfunction, insulin resistance (IR) and atherosclerosis. Moreover, there is evidence that oxidative stress …

Reversal of gastric plication after laparoscopic adjustable gastric banded plication.

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Authors: Goel R, Chang PC, Huang CK
PMID: 22178564 [PubMed – as supplied by publisher] (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)

Comment on: An online bariatric surgery information session is as effective as an in-person information session.

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Authors: Metcalf BN
PMID: 22197463 [PubMed – as supplied by publisher] (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)

Tipping the balance: the pathophysiology of obesity and type 2 diabetes mellitus.

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This article discusses the pathophysiology of type 2 diabetes mellitus and obesity and provides a basic understanding of these diseases, which forms the basis for understanding the importance of weight loss in their treatment.
PMID: 22054144 [PubMed – in process] (Source: The Surgical Clinics of North America)

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Physiology of weight loss surgery.

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Authors: Park CW, Torquati A
Abstract
The clinical outcomes achieved by bariatric surgery have been impressive. However, the physiologic mechanisms and complex metabolic effects of bariatric surgery are only now beginning to be understood. Ongoing research has contributed a large amount of data and shed new light on the science behind obesity and its treatment, and this article reviews the current understanding of metabolic and bariatric surgery physiology.
PMID: 22054145 [PubMed – in process] (Source: The Surgical Clinics of North America)

The economic costs of obesity and the impact of bariatric surgery.

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Authors: Richards NG, Beekley AC, Tichansky DS
Abstract
The obesity epidemic has far-reaching implications for the economic and health care future in the United States. Treatments that show reduction in health care costs over time should be approved and made available to as many patients as possible. It is our opinion that bariatric surgery meets this criterion. However, bariatric surgery cannot provide the impact necessary for reduction in health care and economic costs on a national scale. The obesity epidemic must be addressed by policy efforts at the local, state, and national levels. As experts on obesity, bariatric surgeons must be prepared to guide and inform these efforts.
PMID: 22054147 [PubMed – in process] (Source: The Surgical Clinics of North America)

The history and evolution of bariatric surgical procedures.

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Authors: Baker MT
Abstract
The search for the ideal weight loss operation began more than 50 years ago. Surgical pioneers developed innovative procedures that initially created malabsorption, then restricted volume intake, and eventually combined both techniques. Variations, alterations, and modifications of these original procedures, combined with intense efforts to follow and document outcomes, have led to the evolution of modern bariatric surgery. More recent research has focused on the hormonal and metabolic effects of these procedures. These discoveries at the cellular level will help develop possible mechanisms of weight loss and comorbidity reduction beyond the traditional explanation of reduced food consumption and malabsorption.
PMID: 22054148 [PubMed – in process] (So…

Surgical Treatment for Morbid Obesity: The Laparoscopic Roux-en-Y Gastric Bypass.

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Authors: Powell MS, Fernandez AZ
Abstract
Over the past 20 years bariatric surgery proved to be a valid treatment for reduction and elimination of obesity-related diseases and long-term sustainable weight loss. Minimally invasive or laparoscopic techniques such as laparoscopic Roux-en-Y (LRNY) have replaced open procedures. Many factors play important roles in the small intricacies and variations of the procedure, chief of which is the creation and size of the gastrojejunostomy. Regardless of the variations in technique, the LRNY remains the gold standard for the surgical treatment of clinically severe or morbid obesity, with relatively low morbidity and mortality.
PMID: 22054149 [PubMed – in process] (Source: The Surgical Clinics of North America)

Complications of Laparoscopic Roux-en-Y Gastric Bypass.

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Authors: Al Harakeh AB
Abstract
Despite the well-documented safety of laparoscopic RYGB, several short-term and long-term complications, with varying degrees of morbidity and mortality risk, are known to occur. Bariatric surgeons, all too familiar with these complications, should be knowledgeable in risk-reduction strategies to minimize the incidence of complication occurrence and recurrence. Bariatric and nonbariatric surgeons who evaluate and treat abdominal pain should be familiar with these complications to facilitate early recognition and intervention, thereby minimizing the associated morbidity and mortality.
PMID: 22054150 [PubMed – in process] (Source: The Surgical Clinics of North America)

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